MIC 2023 Schedule of Events

Wednesday, MAY 24TH, AFTERNOON

11:30 am	LUNCH AND REGISTRATION OPENS (UMN Coffman Memorial Union Great Hall, ground floor)
1:00 pm	Welcome Dr. Peter Crawford, MD, PhD, Professor, Associate Dean of Research Operations, University of Minnesota Medical School Dr. Berhard Hering, MD, Professor, Executive Director, Schultz Diabetes Institutes, University of Minnesota
1:10 pm	Introduction Emilyn U. Alejandro, PhD, Associate Professor of Medicine, McKnight Presidential Fellow, Department of Integrative Biology and Physiology, University of Minnesota.

Session I: Islet Cell Development and Function

Chair – Daniele Dean PhD, Vanderbilt University

1:30 pm	Acute MAFB Deficiency Compromises Alpha Cell Activity and Identity in Adult Human Pseudoislets. Katie Coate, Vanderbilt University
1:45 pm	A Method for the Generation of Human Stem Cell-derived Pancreatic Delta cells. Sharath Belame Shivakumar, Mayo Clinic
2:00 pm	Leucine Reduces Glucagon Secretion by Directly Modulating Alpha Cell cAMP. Emily Knuth, University of Wisconsin-Madison
2:15 pm	Islet Architecture in Adult Mice is Actively Maintained by Robo2 Expression in Beta Cells. Bayley Waters, University of Wisconsin-Madison
2:30 pm	Sel1L-Hrd1 Endoplasmic Reticulum-Associated Degradation Regulates PC2 Function and Proglucagon Processing in Islet Alpha Cells. Rachel Reinert, University of Michigan
2:45 pm	COFFEE BREAK (Auditorium Foyer)

Session II: Islet Immunity and Response to Inflammation

Chair – Andrew Templin PhD, Indiana University

3:15 pm	Islets Encapsulated with CTLA-4-Ig and Antioxidants Restore Euglycemia in Subcutaneous Transplant Site. KaLia Burnette, University of Kansas
3:30 pm	The Role of Nitric Oxide in Encephalomyocarditis Viral Replication in Pancreatic Beta Cells. Alyssa Fernandez-Gehant, Medical College of Wisconsin
3:45 pm	β Cell Heterogeneity in the IFN-α Response. Leslie Wagner, Indiana University
4:00 pm	BET Bromodomain Inhibition Attenuates Transcription of Select Cytokine-induced Inflammatory Gene Targets in Pancreatic Beta-cells. Joshua Nord, Medical College of Wisconsin
4:15 pm	Sex Differences in Human Islet Transcriptional Responses to Inflammation. Kierstin Webster, University of Chicago
4:30 pm	Elucidating Mechanisms of Checkpoint-induced Autoimmune Diabetes Pathogenesis in the NOD Mouse with a Normalized Microbial Experience. Zachary Shaheen, University of Minnesota
4:45 pm	Break and Poster Set up (Great Johnson Room and Ski-U-Mah at McNamara Center), room available after 4p.m.

Cocktail hour and Poster Session (Great Johnson Room and Ski-U-Mah at McNamara Alumni Center)

6:00-6:45 pm

Poster Teasers and Preview
Moderators: Aleksey Matveyenko, PhD and Quinn Peterson, PhD, Mayo Clinic

Award Ceremony and Banquet Dinner (Memorial Hall at McNamara Center)

7:00 pm	Award Ceremony Emilyn Alejandro, PhD and Daniel Garry, MD, PhD Robert L. Sorenson PhD - Midwest Islet Club, Lifetime Achievement Award Rafael Arrojo e Drigo PhD - Robert L. Sorenson Young Investigator Award
7:30 pm	Banquet Dinner

General Poster Session (Great Johnson Room and Ski-U-Mah at McNamara Center)

8:30 - 11:00 pm

Poster Session and Mixer

Thursday, MAY 25TH, MORNING

8:00-8:50 am

Breakfast (UMN Coffman Memorial Union Great Hall)

Session III: Clinical and Translation Islet Studies

Chair –Melena Bellin MD, University of Minnesota

9:00 am	Viral Gene Therapy for Streptozotocin-diabetes in Non-human Primates Shiho Yoshida, UPMC Children’s Hospital of Pittsburgh
9:15 am	The Impact of Etanercept and Alpha-1 Antitrypsin on Islet Autotransplantation Outcomes Tasneem Abdel-Karim, University of Minnesota
9:30 am	The Effect of Glucagon-Like Peptide-1 Receptor Blockade on the β-cell Response to Glucagon Bolus in People With and Without Type 2 Diabetes Aoife Egan, Mayo Clinic
9:45 am	Naturally Purified Islets in Total Pancreatectomy (TP) and Islet Autotransplant (IAT) for Chronic Pancreatitis (ChP) Model to Evaluate Impact of Exocrine Co-transplant on Graft Function Siri Larsen, University of Minnesota
10:00 am	Anti-serpinB13 Antibodies Stimulate Beta-cell Development via Notch Signaling Pathway and Delay Progression to Insulin-dependent Diabetes. Yury Kryvalap, University of Minnesota
10:15 am	COFFEE BREAK (Coffman Auditorium Foyer)

Session IV: Islet Response in Pregnancy

Chair – Robert L. Sorenson PhD, University of Minnesota

10:45 am	Introduction of the session by Robert L. Sorenson PhD
11:00 am	Functional Adaptations to Maternal Overnutrition and Metformin Intake in Non-human Primate Offspring Islets. Darian Carroll, Vanderbilt University
11:15 am	Hypertensive Disorder of Pregnancy Results in Loss of Beta Cell Area and Phenotypic Changes in Glucose Handling in Rat Offspring. Kate Root, University of Minnesota-Duluth
11:30 am	Beta-cell IRS1 Deficiency Predisposes Female Mice to Developing Gestational Diabetes. Xingchun Wang, University Pittsburgh
11:45 am	Loss of Tcf19 in Pregnancy Leads to Increased Islet DNA Damage. Joseph Blumer, University of Wisconsin-Madison
12:00 pm	Placental mTOR Signaling Links Nutrient Transport and Offspring Islet Insulin Secretion in Early Life in Mice. Megan Beetch, University of Minnesota
12:15 pm	Lunch (Great Hall, Coffman, ground floor)

Thursday, MAY 25TH, AFTERNOON

Session V: Novel Insights into Regulation of Beta cell Identity and
Function.

Chair – Zong Wei PhD, Mayo Clinic

1:15 pm	Thapsigargin-induced Beta-cell Death is Regulated by RIPK1 Independent of Caspase 3/7 Activity In Vitro. Christopher Contreras, Indiana University
1:30 pm	Lipotoxicity-induced Beta Cell Small Extracellular Vesicles Promote β- cell Functional Failure Through Activation of the TGFβ/Smad3 Pathway. Alexandra Hoff, Mayo Clinic
1:45 pm	Synchronized Proinsulin Trafficking Reveals Delayed Golgi Export Accompanies β-cell Secretory Dysfunction in a Rodent Model of Hyperglycemia. Cierra Boyer, University of Iowa
2:00 pm	The Role of Traf6 in Pancreatic Beta-cell Health and Mitochondrial Function. Elena Levi-D'Ancona, University of Michigan
2:15pm	Perilipin 2 Prevents Lipophagy and Protects Mitochondria from Fatty Acid Overload in Beta Cells. Spencer Peacheé, University of Iowa
2:30pm	Dynorphin, a Novel Paracrine Factor That Regulates Insulin Secretion. Manuel Blandino-Rosano, University of Miami
2:45pm	COFFEE BREAK (Coffman Theater Foyer)

Session VI: Novel Insights into Regulation of Beta cell Identity and Function 2.

Chair – Naureen Javeed PhD, Mayo Clinic

3:15 pm	GABA Modulates Ca2+ Oscillations in Pancreatic Beta-cells Through GABAA Receptor. Sandra Ferreira, University of Florida
3:30 pm	Glucocorticoid Receptor Signaling Regulates Pancreatic Beta Cell Circadian Transcriptome and Function. Satish Sen, Mayo Clinic
3:45 pm	Single Cell Multiomic Analysis Reveals Diabetes-associated β-cell Heterogeneity Driven by HNF1A. Anniya Gu, Case Western Reserve University
4:00 pm	Islet Zinc Turnover is Lower in Murine Beta Cells Expressing the T2DM Risk Variant R at SNP rs13266634 Compared to Islets Expressing the W Variant in a Humanized ZnT8 Beta Cell Knock-In Murine Model. Malek El Muayed, Northwestern University
4:14 pm	Swi/Snf is Required for β-cell Development and Postnatal Islet Function. Becca Davidson, Indiana University
4:30 pm	Caloric Restriction Modifies Beta Cell Structure-function and Longevity. Cristiane dos Santos, Vanderbilt University
5:00 pm	BREAK

PAUL LACY MEDAL PRESENTATION AND LECTURE
McNamara Memorial Hall

6:00 pm	Midwest Islet Club Presentation and Poster Awards Quinn Peterson, PhD, Mayo Clinic
6:15 pm	Lacy Medal Lecture Introduction Aleksey Matveyenko, PhD, Mayo Clinic and Maria Golson, PhD, Johns Hopkins University
6:30 pm	2023 Lacey Medal Lecture Maureen Gannon PhD, Vanderbilt University
7:30pm	Concluding Remarks MIC Organizers
7:40 pm	Banquet Dinner
9:00 pm - 11:00 pm	Entertainment

Scientific Sessions: May 24-25

MIC 2023 Schedule of Events

PAUL LACY MEDAL PRESENTATION AND LECTURE McNamara Memorial Hall

PAUL LACY MEDAL PRESENTATION AND LECTURE
McNamara Memorial Hall